Adrienne Boire, M.D., Ph.D. is the Geoffrey Beene Junior Faculty Chair at Memorial Sloan Kettering Cancer Center in New York. As a neuro-oncologist, she cares for patients with metastasis to the central nervous system (CNS), with particular focus on leptomeningeal metastasis.  As a scientist, she runs a laboratory-based research program focused on leptomeningeal metastasis. Her team employs multi-omic analysis of human samples to identify cancer cell adaptations to the challenging microenvironment of the leptomeninges. Leveraging mouse models, in vitro modeling, and classical biochemical techniques, the team uncovers the mechanistic implications of these discoveries to understand the biology of the leptomeningeal space and establish novel therapies for leptomengingeal metastasis.