Daniel
Dwyer
After completing my undergraduate studies at Amherst College, I joined the Harvard Medical School Immunology Ph.D. program under the mentorship of Dr. K. Frank Austen, where I studied the initiation of allergic inflammation with a focus on B cells and mast cell progenitors. My interest in the mechanisms of allergic inflammation continued during my post-doctoral research with Dr. Nora Barrett at Brigham and Women’s Hospital, where I used transcriptomics to define murine mast cell heterogeneity across tissues and single-cell RNA sequencing to define key cellular players and map mast cell heterogeneity within human nasal polyposis. I started my independent laboratory at Brigham and Women’s Hospital in Fall 2019, where my research has focused on determining the signals that recruit mast cell progenitors from the circulation to inflamed tissues, understanding how these progenitors integrate tissue- and inflammation-associated signals to take on a range of discrete phenotypes, and discovering how heterogeneous mast cell phenotypes influence both tissue homeostasis and disease progression.